孔武有力的瑞迪克（范·迪塞尔 Vin Diesel 饰）终于坐上组织的宝座，强兵悍将拜倒阶下，与此同时又有更多野心家蠢蠢欲动，时刻准备取代他的位置
直到某天，瑞迪克被亲信哄骗离开舰队，启程返回阔别已久的家乡，谁知竟被带到一颗充满凶险的蛮荒星球，进而更遭到随从的背叛和追杀 侥幸逃得一命的瑞迪克满身伤痕，而这颗行星上到处都是凶猛的野兽和可怕的异形 为了求生，他只有将自己化身为杀气十足的杀神，以驯服这群时时刻刻想要吃掉他的异界生物 当然，更大的挑战和危险远远不止这些，迪瑞克依然活着的消息传遍全宇宙，由此引来一波又一波的赏金猎人试图割下他的脑袋
生死之战，在陌生的星球展开
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